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What is the structure of a statin?

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You must be curious about how this specific medical compound is structured. Statins' active component is a 3, 5-dihydroxyglutaric acid moiety that binds to HMG-CoA reductase and inhibits its activity in a stereo-selective process that requires the statin to have a 3R, 5R configuration.

The main clinical differences between various statins are due to the ring attached to the active moiety which can be made up of pyrrole, pyridine, or quinoline, etc. The solubility and pharmacological properties of the statin are explained by the substituents present on the ring, which can range from a number of different chemicals.

All statins are substrates of several membrane transporters.

 Enough with the technical terminologies! All in all, statins might have a bad name in the medical market but they truly aren't as harsh as the world deems them to be. So if you do want to battle cholesterol, you might want to give them a try.

 

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