BERGAMET STAT10™

A 2018 meta-analysis of randomized controlled trials (RCTs) published in Atherosclerosis examined the effects of CoQ10 on patients with cardiovascular disease. Results showed significant improvements in endothelial function and reductions in oxidative stress markers. The study concluded that CoQ10 supplementation could enhance heart health, particularly in patients on statins, by reducing statin-related side effects such as muscle pain and fatigue.

• Reference: Zhai, J., et al. (2017). Coenzyme Q10 for the treatment of cardiovascular diseases: A systematic review of meta-analyses. Atherosclerosis, 260, 6-16.

The Omega-3 fatty acids in fish oil have been extensively studied for their cardiovascular benefits. A notable study, the REDUCE-IT trial (2018), published in the New England Journal of Medicine, demonstrated that high-dose EPA (eicosapentaenoic acid), a type of Omega-3, significantly reduced major cardiovascular events by 25% in patients with elevated triglyceride levels despite statin therapy.

• Reference: Bhatt, D. L., et al. (2019). Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. New England Journal of Medicine, 380(1), 11-22.

A 2017 clinical trial published in Metabolism assessed the effects of berberine on cholesterol and glucose metabolism in patients with metabolic syndrome. The study found that berberine significantly reduced LDL cholesterol and triglycerides while improving insulin sensitivity and lowering fasting blood glucose levels, suggesting potential benefits for cardiovascular health.

• Reference: Wei, W., et al. (2017). Berberine for the treatment of metabolic syndrome in humans: A systematic review. Metabolism, 66, 85-93.

A 2016 clinical study published in Frontiers in Pharmacology investigated the impact of bergamot polyphenolic extract on cholesterol levels in patients with hyperlipidemia. The results demonstrated a significant reduction in LDL cholesterol and an increase in HDL cholesterol after 30 days of supplementation, highlighting its potential for supporting cardiovascular health.

• Reference: Mollace, V., et al. (2016). Hypolipemic and hypoglycemic activity of bergamot polyphenols: From animal models to human studies. Frontiers in Pharmacology, 7, 182.

A 2013 meta-analysis published in American Journal of Clinical Nutrition reviewed multiple studies on resveratrol and its cardiovascular effects. The analysis showed that resveratrol supplementation improved endothelial function, reduced blood pressure, and had anti-inflammatory effects, all of which contribute to better heart health.

• Reference: Liu, Y., et al. (2015). Effect of resveratrol on blood pressure: A systematic review and meta-analysis of randomized, controlled trials. American Journal of Clinical Nutrition, 100(5), 1181-1191.

A 2012 meta-analysis published in the American Journal of Clinical Nutrition examined the effects of vitamin C supplementation on blood pressure. The analysis included 29 randomized controlled trials and found that vitamin C supplementation resulted in modest but significant reductions in both systolic and diastolic blood pressure. Specifically, systolic blood pressure decreased by an average of 3.84 mm Hg, and diastolic blood pressure decreased by 1.48 mm Hg. These results highlight vitamin C’s potential role in supporting cardiovascular health, particularly in blood pressure management.

 • Reference: Juraschek, S. P., et al. (2012). Effects of vitamin C supplementation on blood pressure: A meta-analysis of randomized controlled trials. American Journal of Clinical Nutrition, 95(5), 1079-1088.